The effects of hierarchical micro/nanosurfaces decorated with TiO2 nanotubes on the bioactivity of titanium implants in vitro and in vivo

• DOI: 10.2147/ijn.s87347
• Publication Date: 2015-11-10T01:31:44Z
• Authors: Lei Zhou; Xianglong Ding; Jingxu Wang; Qingxia Zhao; Xi Lin; Yan Gao; Shaobing Li; Jingyi Wu; Mingdeng Rong; Zehong Guo; Chunhua Lai; Haibin Lu; Fang Jia
• Keywords: Male; 0301 basic medicine; Surface Properties; Fluorescent Antibody Technique; 02 engineering and technology; 03 medical and health sciences; Dogs; International Journal of Nanomedicine; Osseointegration; Cell Line, Tumor; Cell Adhesion; Animals; Humans; RNA, Messenger; Cell Shape; Original Research; Cell Proliferation; Titanium; 2. Zero hunger; Nanotubes; Water; Prostheses and Implants; 3. Good health; Gene Expression Regulation; Adsorption; 0210 nano-technology

Abstract: In the present work, a hierarchical hybrid micro/nanostructured titanium surface was obtained by sandblasting with large grit and acid etching (SLA), nanotubes of different diameters (30 nm, 50 80 nm) were superimposed anodization. The effect each SLA-treated decorated (SLA + 30 SLA on osteogenesis studied in vitro vivo. human MG63 osteosarcoma cell line used for cytocompatibility evaluation, which showed that adhesion proliferation dramatically enhanced nm. comparison cells grown other tested surfaces, those nm an expression osteogenesis-related genes. Cell spread also A canine model vivo evaluation bone bonding. Histological examination demonstrated new formed more rapidly surfaces (especially than without nanotubes. All these results indicate is favorable promoting activity osteoblasts early Keywords: nanotopography, osseointegration, dental orthopedic implant,