A nanomedicine-promising approach to provide an appropriate colon-targeted drug delivery system for 5-fluorouracil

• DOI: 10.2147/ijn.s89030
• Publication Date: 2015-11-24T01:29:49Z
• Authors: Thomas J Webster; Sima Singh; Niranjan Kotla; Sonia Tomar; Balaji Maddiboyina; Dinesh Sharma; Omprakash Sunnapu
• Keywords: Targeted drug delivery; Guar gum

A nanomedicine-promising approach to provide an appropriate colon-targeted drug delivery system for 5-fluorouracil Sima Singh,1,* Niranjan G Kotla,2,* Sonia Tomar,3 Balaji Maddiboyina,4 Thomas J Webster,5,6 Dinesh Sharma,7 Omprakash Sunnapu2 1Department of Pharmaceutical Sciences and Technology, Birla Institute Mesra, Ranchi, Jharkhand, 2Technologies the Advancement Science, Stem Cell Biology Regenerative Medicine, Bangalore, Karnataka, 3Department Pharmaceutics, Ram Gopal College Pharmacy, Rohtak, Haryana, 4Department Maharishi Markandeshwar University, Mullana, Ambala, India; 5Department Chemical Engineering, Northeastern Boston, MA, USA; 6Center Excellence Advanced Materials Research, King Abdulaziz Jeddah, Saudi Arabia; 7Ranbaxy Laboratory Ltd, Gurgaon, India *These authors contributed equally to this work Abstract: Targeted plays a significant role in disease treatment associated with colon, affording therapeutic responses prolonged period time low side effects. Colorectal cancer is third most common both men women estimated 102,480 cases colon 40,340 rectal 2013 as reported by American Cancer Society. In present investigation, we developed improved oral existing anticancer drugs meant via prebiotic probiotic approaches. The comprises three components, namely, nanoparticles coated natural materials such guar gum, xanthan gum (that serve prebiotics), probiotics. gums play dual protecting gastric well intestinal conditions allow its release only colon. vitro results obtained from these experiments indicated successful targeted Electron microscopy demonstrated that prepared were spherical shape 200 nm size. data maximum occurs at pH 7.2 7.4 93% released presence 4% (w/v) rat cecal content. vivo conclude practical mechanism maintain integrity intactness intestinal/colonic microflora, face “chemical attack” treatment. Keywords: colon-specific system, polymeric nanoparticles, probiotics,