Enhanced antitumor effects by docetaxel/LL37-loaded thermosensitive hydrogel nanoparticles in peritoneal carcinomatosis of colorectal cancer

• DOI: 10.2147/ijn.s89066
• Publication Date: 2015-12-04T01:42:14Z
• Authors: Liangxue Zhou; Rangrang Fan; Aiping Tong; Xiaoling Li; Xiang Gao; Lan Mei; Xiaoning Zhang; Chao You; Gang Guo
• Keywords: Polylactic Acid

Abstract: Intraperitoneal chemotherapy was explored in clinical trials as a promising strategy to improve the therapeutic effects of chemotherapy. In this work, we developed biodegradable and injectable drug-delivery system by coencapsulation docetaxel (Doc) LL37 peptide polymeric nanoparticles (Doc+LL37 NPs) thermosensitive hydrogel for colorectal peritoneal carcinoma therapy. Firstly, polylactic acid (PLA)-Pluronic L35-PLA (PLA-L35-PLA) prepare Doc+LL37 NPs using water-in-oil-in-water double-emulsion solvent-evaporation method. Then, PLA-L64-PLA with lower sol–gel transition temperature at around body also prepared. Transmission electron microscopy revealed that formed PLA-L35-PLA copolymer were spherical. Fourier-transform infrared spectra certified Doc encapsulated successfully. X-ray diffraction diagrams indicated amorphously. administration NPs–hydrogel significantly suppressed growth HCT116 carcinomatosis vivo prolonged survival tumor-bearing mice. Our results suggested may have potential applications. Keywords: intraperitoneal chemotherapy, injectable, nanoparticles, hydrogel,