Continuous follicle-stimulating hormone exposure from pituitary adenoma causes periodic follicle recruitment and atresia, which mimics ovarian hyperstimulation syndrome

• DOI: 10.2147/ijwh.s33386
• Publication Date: 2012-08-24T02:30:54Z
• Authors: Tsuyoshi Baba; Kanaya; Kitajima; Honnma; Ikeda; Shimizu; Morishita; Toshiaki Endo; Saito
• Keywords: Ovarian hyperstimulation syndrome; Controlled ovarian hyperstimulation

Follicle-stimulating hormone (FSH)-secreting pituitary adenoma is usually a nonfunctioning tumor, but in rare cases it may develop into ovarian hyperstimulation. Several reports have revealed that serum FSH levels are normal to slightly high patients with combined FSH-secreting This finding different from iatrogenic hyperstimulation syndrome (OHSS), which associated extremely of FSH.To describe the clinical course two who developed OHSS adenoma.Endocrine studies were or increased, luteinizing low undetectable. Their estradiol (E2) intriguing: fluctuated drastically over 6 weeks Case 1, stayed flat 2. Ultrasonographic examinations showed bilaterally enlarged multicystic ovaries, and magnetic resonance imaging indicated tumors. Transsephenoidal resection tumors ameliorated symptoms pathological diagnosis adenomas.As not case OHSS, even small moderate amount stimulation, continuously secreted by adenoma, can cause Although hyperstimulation, an E2 biosynthesis granulosa cells seldom occurs.