The Impact of Biological Therapies and the Significance of Their Adherence on Asthma Outcomes in a Single Tertiary Asthma Center

• DOI: 10.2147/jaa.s522414
• Publication Date: 2025-05-05T08:25:14Z
• Authors: Riyad Al-Lehebi; Razan Kharraz; Ohud Alreshidi
• Keywords: Tertiary care; Center (category theory); Single Center

Biological therapies have revolutionized the approach to treating asthma. This retrospective study evaluates biologics impact on asthma outcomes, clinical remission, adherence prevalence, and influence of outcomes. Baseline characteristics post-therapy changes were analysed, was measured using percentage days covered with therapy (PDC%). A total 67 patients initiated included. Clinical improvements statistically significant outcomes observed across all biologics, including reduced attacks, a lower dose daily steroids, improved symptom control FEV1. remission achieved in 24% those who started biologics. Patients demonstrated high first year (average PDC% 86%), though modest decline 84.5% noted following year. Logistic regression revealed that trends not significantly associated worsening cohort. These findings underscore importance sustained patient support education maintaining biological therapies, which can lead and, some cases, remission. The highlights potential personalized treatment strategies adherence-focused programs optimize management, particularly severe patients. Future research should explore long-term patterns patient-specific factors success.