<p>Serum homocysteine and disease severity in sickle cell anemia patients in Lagos</p>

• DOI: 10.2147/jbm.s198316
• Publication Date: 2019-05-07T22:52:33Z
• Authors: Ebele Uche; Oluwaseun Adelekan; Akinsegun Akinbami; Vincent Osunkalu; Kamal Ismail; Ann Abiola Ogbenna; Mulikat Badiru; Adedoyin Dosunmu; Esther Oluwole; Omolara Kamson
• Keywords: Journal of Blood Medicine; 03 medical and health sciences; 0302 clinical medicine; Sickle cell anaemia; disease severity; Diseases of the blood and blood-forming organs; homocysteine; RC633-647.5; Original Research; 3. Good health

Purpose: Hypercoagulability in sickle cell anemia (SCA) may be responsible for the increased development of vascular occlusion certain organs as well acute pain episodes. The causes hypercoagulability SCA are multifactorial and include raised homocysteine levels. This study, therefore, aimed to determine serum levels patients steady state correlate its with disease severity. Patients Methods: was a cross-sectional study done among attending Haematology Clinic Lagos State University Teaching Hospital (LASUTH). Matched age sex HbAA controls were also recruited. Serum each participant enzyme-linked immunosorbent assay severity score assessed every patient using clinical laboratory parameters. Results: mean value group (SCA patients) 19.80±19.75 μmol/L whilst that control 9.16±4.29 μmol/L. Thirty-nine out 96 (46.6%) had elevated (>15 μmol/L) all participants normal difference means two groups statistically significant p =0.001. Majority (62.5%) mild (severity ≤3). There correlation between scores =0.04; χ 2, =4.04. Conclusion: Homocysteine significantly higher HbSS compared matched showed positive patients. Keywords: anemia, severity,