Effects of the Oral Administration of Aqueous and Methanolic Leaf Extracts of Chenopodium ambrosioides L. (Amaranthaceae) on Blood Glucose Levels in Wistar Rats

• DOI: 10.2147/jep.s356564
• Publication Date: 2022-04-25T15:40:22Z
• Authors: Félicien Mushagal...; Justin Ntokamunda...; Jonans Tusiimire; Clement Olusoji A...; Amon Ganafa Agaba
• Keywords: Vernonia amygdalina; Maceration (sewage)

Diabetes mellitus is a metabolic disorder that poses major global health threat. The current diabetes uses insulin and oral hypoglycemic agents, which have limitations, including adverse effects secondary failures. Herbal medicine being evaluated for its role in the pharmacotherapy of diabetes. This study was aimed to assess anti-diabetic potential short-term toxicity level Chenopodium ambrosioides collected from Bukavu Democratic Republic Congo.Leaves C. were extracted by infusion maceration with distilled water 95% methanol, respectively. Hypoglycemic antihyperglycemic potentials aqueous methanolic investigated normoglycemic intraperitoneal glucose-loaded rats at 100, 200, 400 mg/kg body weight. An acute test carried out on healthy female Wistar rats.Acute showed mean lethal dose (LD50) both methanol extracts be more than 2000 mg/kg. group treated glibenclamide (5 b.w) extract plant (200 significant reduction (p< 0.0001 p< 0.05) fasting blood glucose 46.91% 16.72%, respectively, compared control all other treatment groups. In conditions, single administration lowered rats. Any manifestation signs mortality been recorded 14 days observation.Leaf appeared safe demonstrated some rats, explaining use as an remedy locally.