<p>Cross-Linked Multimeric Pro-Peptides of Type III Collagen (PC3X) in Hepatocellular Carcinoma – A Biomarker That Provides Additional Prognostic Value in AFP Positive Patients</p>

• DOI: 10.2147/jhc.s275008
• Publication Date: 2020-11-08T21:02:11Z
• Authors: Christina Jensen; Signe Holm Nielsen; Mohammed Eslam; Federica Genovese; Mette Juul Nielsen; Roslyn Vongsuvanh; Raj Uchila; David van der Poo...; Jacob George; Morten Asser Karsdal; Diana Julie Leeming; Nicholas Willumsen
• Keywords: Value (mathematics)

Non-invasive biomarkers for diagnosing and prognosing hepatocellular carcinoma (HCC) are urgently needed. Cirrhosis is present in 80-90% of HCC patients. characterized by deposition cross-linking collagens that have crucial roles initiation progression. We evaluated circulating cross-linked pro-peptides type III collagen (PC3X) as a diagnostic prognostic biomarker HCC.PC3X was measured ELISA plasma from patients with (n=79), cirrhosis (n=86), non-cirrhotic hepatitis-B infection (n=74) healthy controls (n=44). PC3X compared to the liver fibrosis marker PRO-C3 tumor-cell derived alpha-fetoprotein (AFP). Diagnostic potential AUROC calculating hazard ratios (HR) progression-free survival (PFS) overall (OS).PC3X, AFP were significantly elevated other diseases (p=0.0002, p<0.0001). In normal (<20 IU/mL), separated an 0.72 0.68, respectively. High predicted poor PFS (HRPC3X=1.80, p=0.032; HRAFP=1.70, p=0.031) OS (HRPC3X=2.12, p=0.024; HRAFP=2.55; p=0.003), whereas did not (PFS: HR=1.19, p=0.059 OS: HR=1.12, p=0.324). independent HR=1.74, p=0.045 HR=2.21, p=0.018) combining two improved value HR=2.66, p=0.004 HR=5.86, p<0.0001).PC3X associated provides If validated, this suggests has HCC.