A Genetic Variant of PPP1CB Influences Risk of Hepatitis B Virus-Related Hepatocellular Carcinoma in Han Chinese: A Pathway Based Analysis

• DOI: 10.2147/jhc.s321939
• Publication Date: 2021-09-02T11:20:15Z
• Authors: Haoming Mai; Haisheng Xie; Jia Hou; Haitao Chen; Bin Zhou; Jinlin Hou; Deke Jiang
• Keywords: Genome-wide Association Study; SNP; KEGG; CTCF

Purpose: Activation of actin cytoskeleton remodeling is an important stage preceding cancer cell metastasis. Previous genome-wide association studies (GWAS) have identified multiple hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)-associated risk loci. However, limited sample size or strict significance threshold GWAS may cause HBV-related HCC risk-associated genetic loci to be undetected. We aimed investigate the performance SNP rs13025377 in PPP1CB HCC. Patients and Methods: performed a case–control study including 1161 cases 1353 controls evaluate associations between single nucleotide polymorphisms (SNPs) from 98 actin-cytoskeleton regulatory genes The effects SNPs on were assessed under logistic regression model corrected by false discovery rate (FDR). Results: found that was significantly associated with [odds ratio (OR) = 0.81, 95% confidence interval (CI) 0.72∼ 0.91, P 4.88× 10 – 4 ]. allele A increased expression levels normal liver tissue. rs4665434 tagged (r 2 0.9) its protective disrupted CTCF Cohesin motifs. According public datasets, PPP1CB, are tumor tissues. Kaplan–Meier plots demonstrated higher shorter overall survival (OS). Moreover, we observed strong correlation CTCF, , various Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analysis confirmed plays role through regulation. Conclusion: Thus, these findings indicated key gene regulation contributes regulating expression. Keywords: studies, cohesin, SNP,