The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy

• DOI: 10.2147/jir.s103697
• Publication Date: 2016-05-06T00:56:35Z
• Authors: Vania Piatto; Marta Lucia Gabriel; Fernanda Del Camp...; Mariana Ribeiro R...; Ana Cláudia Polli...; Antonio Soares Souza
• Keywords: Periventricular leukomalacia; Proinflammatory cytokine

Periventricular leukomalacia (PVL) is a frequent consequence of hypoxic-ischemic injury. Functional cytokine gene variants that result in altered production inflammatory (tumor necrosis factor-alpha [TNF-α] and interleukin-1beta [IL-1β]) or anti-inflammatory (interleukin-10 [IL-10]) cytokines may modify disease processes, including PVL.The aim this study was to evaluate if there relationship between the two proinflammatory polymorphisms (TNF-α-1031T/C IL-1β-511C/T) polymorphism IL-10-1082G/A PVL risk Brazilian newborns with without injury.A cross-sectional case-control performed at Neonatal Intensive Care Unit Children's Hospital Maternity São José do Rio Preto Medical School (FAMERP). Fifty preterm term were examined as index cases 50 controls, both sexes for groups. DNA extracted from peripheral blood leukocytes, sites encompassed three amplified by polymerase chain reaction-restriction fragment length polymorphism.Gestational age ranged 25 39 weeks, case group, control group it 38 42.5 weeks (P<0.0001). Statistically significant association found TNF-α-1031T/C high expression genotype TC (odds ratio [OR], 2.495; 95% confidence interval [CI], 1.10-5.63; P=0.043) well genotypes (TC + CC) (OR, 2.471; CI, 1.10-5.55; P=0.044) PVL. IL-1β-511C/T (CT TT) 23.120; 1.31-409.4; P=0.003) GG 0.07407; 0.02-0.34; P<0.0001) IL-10-1082G allele 0.5098; 0.29-0.91; P=0,030) reduced observed. There statistically TC/CT/GA combination 6.469; 2.00-20.92; P=0.001).There evidence an TNF-α-1031T/C, IL-1β-511C/T, newborn population studied.