Resistin Concentration in Early Sepsis and All-Cause Mortality at a Safety-Net Hospital in Riverside County

• DOI: 10.2147/jir.s370788
• Publication Date: 2022-07-12T12:20:06Z
• Authors: Jeffrey Bonenfant; Jiang Li; Luqman Nasouf; Joseph Miller; Tammy Lowe; Lukasz Jaroszewski; Xinru Qiu; Suman Thapamagar; Aarti Mittal; Adam Godzik; Walter Klein; Meera Nair
• Keywords: Resistin; SOFA score

Sepsis mortality has remained unchanged for greater than a decade, and early recognition continues to be the most important factor in outcome. Plasma resistin concentration is increased sepsis, but its mechanism clinical relevance unclear. As one function, interacts with toll-like receptor 4 competition lipopolysaccharide, main component of gram-negative bacterial cell wall. It not known if type infection leading sepsis influences production. The objective this study was investigate whether 1) plasma can predict mortality, 2) elevated associated disease severity scores, such as SOFA, mSOFA APACHE II, 3) concentrations differ between gram negative versus other etiologies sepsis.This an exploratory framework prospective observational design. Peripheral venous blood samples were obtained from subjects admitted intensive care unit at (0 hour) 6 24 hours. Vasopressor utilization requirement inclusion. analyzed by ELISA. Cytokine including IL-6, IL-8, IL-10 determined cytokine bead array. data evaluated against publicly available RNA expression datasets compare protein levels predicting state. Clinical collected electronic health records index calculations context interpretation concentrations. Subjects followed up 60 days, or until death, whichever came first. Statistical analysis completed R package SPSS software.Resistin sepsis. Four-hundred screened 45 included final analysis. Thirteen patients non-survivors. Mortality within days correlated significantly higher survivors. A >126 ng/mL >197 first hours area under curve 0.82 0.88, respectively. Most these threshold values deceased prior 30 days. Resistin mSOFA, II scores addition having association increases inflammatory biomarkers. These associations validated datasets.Plasma are all-cause mortality. timeframe also comparable well-validated indices scores.