U-Shaped Association Between Monocyte-Lymphocyte Ratio and Risk of Cardiac Conduction Block

• DOI: 10.2147/jir.s438722
• Publication Date: 2023-11-17T12:50:12Z
• Authors: Man Li; Xintao Li; Hongwei Gao; Peng Li; Li Zhang; Xiaoling Zhang; Peipei Liu; Xuemei Yang; Lili Wu; Jiangwei Zeng; Shouling Wu; Lixia Sun
• Keywords: Quartile; Monocyte

Inflammation plays a critical role in the development of cardiac conduction block (CCB), which is associated with an increased risk morbidity and mortality. The monocyte-lymphocyte ratio (MLR) acts as novel inflammatory marker; however, its association CCB has not yet been studied. This study aimed to investigate between MLR risk.In total, 82,472 CCB-free participants were identified from Kailuan study. was calculated using monocyte count/lymphocyte count. stratified based on quartiles levels. Incident subtypes ascertained electrocardiograms at biennial follow-up visits. Cox proportional hazards model restricted cubic spline analysis used subtypes.During median 10.4 years, 3222 incident cases observed. A U-shaped observed (Pnonlinearity <0.05). After multivariate adjustment, individuals highest quartile had hazard (HR) 1.212 (95% CI: 1.097-1.340; Q4 vs Q2), while those lowest HR 1.106 1.000-1.224; Q1 Q2). Sensitivity subgroup analyses yielded consistent results. persisted for atrioventricular (AVB) subtype analyses.MLR significantly new-onset CCB. Assessing may have clinical relevance predicting risk, providing valuable insights preventive strategies patient management.The pre-registered trial number ChiCTR-TNC-11001489.