Macrophage-Myofibroblast Transition as a Potential Origin for Skeletal Muscle Fibrosis After Injury via Complement System Activation

• DOI: 10.2147/jir.s450599
• Publication Date: 2024-02-16T12:45:05Z
• Authors: Beijie Qi; Yuqi Li; Zhen Peng; Zhiwen Luo; Xingyu Zhang; Jiwu Chen; Guoqi Li; Yaying Sun
• Keywords: Myofibroblast; KEGG; CD68

Acute skeletal muscle injury is common in sports. The injured cannot fully recover due to fibrosis resulting from myofibroblasts. Understanding the origin of fibroblasts is, therefore, important for development anti-fibrotic therapies. Accumulating evidence shows that a mechanism called macrophage-myofibroblast transition (MMT) can lead tissue or organ fibrosis, yet it still unclear whether MMT exists and exact mechanisms.