The Clinical Association Between the Inflammation-Nutritional Condition and Prognosis of Locally Advanced Intrahepatic Cholangiocarcinoma After R0 Resection: Evidence from Competing Risk and Propensity Matching Analysis

Intrahepatic Cholangiocarcinoma Association (psychology)
DOI: 10.2147/jir.s460103 Publication Date: 2024-05-07T05:20:10Z
ABSTRACT
Background: Intrahepatic cholangiocarcinoma (ICC) correlates with poor outcomes, necessitating the identification of prognostic factors from an inflammation-nutritional perspective in locally advanced ICC patients after R0 resection. Methods: We retrospectively reviewed medical records 159 Sun Yat-sen University Cancer Center. Univariate and multivariate Cox regression analysis, as well competing risk were conducted to explore variables for following surgery. To validate robustness our findings, we performed propensity score matching (PSM) analyses evaluate survival differences based on indexes. Results: Considering non-cancer-specific death factors, both systemic immune-inflammation index (SII, HR: 1.934) nutrition (PNI, 0.604) emerged significant resection (P < 0.05). After PSM, benefit between low high PNI sets remained clear (median time: 15.7 months vs 35.1 months, P = 0.002). Although 5-year overall (OS) rate SII group was higher than that group, difference not statistically (17.5% VS 27.4%, 0.112). Other influencing included tumor number, diameter, preoperative carcinoembryonic antigen (CEA)and carbohydrate 19– 9 (CA19-9) levels, postoperative adjuvant therapy. Conclusion: Individual inflammatory nutritional status significantly impact prognosis undergoing hapectomy. Oncologists should consider incorporating conditions into decision-making process this subset ICC. Keywords: intrahepatic cholangiocarcinoma, inflammation, nutrition, analysis
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