Prevalence, Risk Factors, and Mortality of Invasive Pulmonary Aspergillosis in Patients with Anti-MDA5+ Dermatomyositis: A Retrospective Study in China

• DOI: 10.2147/jir.s460702
• Publication Date: 2024-05-20T08:25:09Z
• Authors: Xixia Chen; Sang Lin; Qiwen Jin; Lu Zhang; Wei Jiang; Xin Lu; Guochun Wang; Yongpeng Ge
• Keywords: Galactomannan

Objective: To investigate the prevalence, risk factors and prognosis of invasive pulmonary aspergillosis (IPA) in patients with anti-melanoma differentiation-associated gene 5 positive dermatomyositis (anti-MDA5+ DM). Methods: A retrospective analysis was conducted anti-MDA5+ DM diagnosed between January 2016 March 2023. Patients lower respiratory tract specimens were categorized into IPA+ IPA- groups based on presence IPA their clinical characteristics prognoses then compared. Results: Of 415 DM, 28 cases had (prevalence rate 6.7%) Aspergillus fumigatus being most common species. The (n=28) (n=98) groups, no significant age or gender-related differences ( P > 0.05). group a lymphocyte count, particularly CD4+ T-cell reduced serum albumin higher ferritin levels all< An elevated bronchoalveolar lavage fluid (BALF) galactomannan level found to be sole independent factor for occurrence (adjusted OR=2.191, =0.029) cut-off value 0.585 area under curve 0.779. mortality 25%. Compared survivors, non-survivors this exhibited incidence rapidly progressive interstitial lung disease, counts, increased co-infection Pneumocystis jirovecii Conclusion: not rare BALF an occurrence. Clinicians must exercise vigilance identify exhibiting aforementioned factors. Keywords: aspergillosis, opportunistic infection, dermatomyositis, factors,