Mangiferin Ameliorates CCl4-Triggered Acute Liver Injury by Inhibiting Inflammatory Response and Oxidative Stress: Involving the Nrf2-ARE Pathway

• DOI: 10.2147/jir.s476288
• Publication Date: 2024-10-04T07:30:21Z
• Authors: Caixing Shi; Yueyao Li; Zhidong You; Yiran Tian; Xiaoyu Zhu; Hao Xu; Menghan Yang; Yutong Zhang; Rui Dong; Huirong Quan; Yongyi Shang; Xiaojin Li
• Keywords: Mangiferin; CCL4; Inflammatory response

Acute liver injury (ALI) is characterized by inflammation and oxidative stress (OS). Although mangiferin (MGF) has antioxidant anti-inflammatory effects, its role in ALI remains unclear. Accordingly, we investigated the MGF molecular mechanism carbon tetrachloride (CCl