Pain aversion and anxiety-like behavior occur at different times during the course of chronic inflammatory pain in rats

• DOI: 10.2147/jpr.s139679
• Publication Date: 2017-11-07T00:50:49Z
• Authors: Yuanyuan Wu; Xinmiao Yao; Yongliang Jiang; Xiaofen He; Xiaomei Shao; Junying Du; Zui Shen; Qiaoying He; Jianqiao Fang
• Keywords: Pain catastrophizing; Central pain

Pain is considered a multidimensional conscious experience that includes sensory component and negative affective-motivational component. The of pain different from the amplifies experience. Nowadays, significant number preclinical research groups have focused their attention on affective symptoms pain. In present study, we investigated aversion anxiety-like behavior complete Freund's adjuvant (CFA)-induced chronic model. CFA rats experienced spontaneous during pain-paired conditioning (pain aversion) produces an response (anxiety-like behavior). Moreover, was gradually attenuated, while increased in 4 weeks. Therefore, although effect (including anxiety) always associated with hyperalgesia, manifestations may follow time courses, which influence progress primary disease. findings illustrate targeted therapy should focus specific aspect stages Our study emphasizes necessity using multiple tests to comorbidities.