Gender Differences in Hippocampal/Parahippocampal Functional Connectivity Network in Patients Diagnosed with Chronic Insomnia Disorder

• DOI: 10.2147/nss.s355922
• Publication Date: 2022-06-21T09:50:09Z
• Authors: Lili Yang; Siyi Yu; Leixiao Zhang; Wei Peng; Youping Hu; Fen Feng; Jie Yang
• Keywords: Dorsolateral prefrontal cortex; Parahippocampal gyrus; Orbitofrontal cortex

Gender differences in hippocampal and parahippocampal gyrus (HIP/PHG) volumes have been reported sleep disorders. Therefore, this study investigated the moderating effect of gender on relationship between chronic insomnia disorder (CID) HIP/PHG functional connectivity (FC) network.For study, 110 patients diagnosed with CID (43 men 67 women) 60 matched good control (GSC) (22 38 were recruited. These participants underwent resting-state magnetic resonance imaging scans, after which a 2 × (diagnosis gender) analysis variance was used to detect main interactive their FC networks.Although HIP network observed bilateral cerebellar tonsil, superior frontal gyrus, medial orbitofrontal cortex, effects PHG amygdala. In contrast, right cerebellum posterior lobe, dorsolateral prefrontal cortex (DLPFC), supplemental motor area. Of note, both FCs dorsal anterior cingulate then DLPFC. Moreover, left DLPFC positively associated anxiety scores female CID.Our identified that brain existed executive CID, these results will eventually extend our understanding important role plays pathophysiology CID.