Clinicopathological significance of <em>p15</em> promoter hypermethylation in multiple myeloma: a meta-analysis

• DOI: 10.2147/ott.s102733
• Publication Date: 2016-07-04T03:06:20Z
• Authors: Yong Feng; Shuhua Yang; Bo Zhang; Bing Wei
• Keywords: Clinical Significance

Published studies reported that loss of function the p15(INK4B) gene is caused by hypermethylation; however, whether or not inactivation associated with incidence and clinical significance multiple myeloma (MM) remains unclear. In this study, we performed a meta-analysis to quantitatively determine effects p15 hypermethylation on MM. The related research articles in English Chinese languages were evaluated. data extracted assessed independently. pooled analyzed odds ratios calculated summarized. Sixteen eligible selected for final analysis. We demonstrated significantly higher MM than normal bone marrow, as well monoclonal gammopathy undetermined significance. However, aberrant was advanced early-stage results study reveal correlated an increased risk progression hypermethylation, which induces gene, plays critical role early tumorigenesis serves reputable diagnostic marker potential drug target.