The clinicopathological significance of <em>hMLH1</em> hypermethylation in non-small-cell lung cancer: a meta-analysis and literature review

• DOI: 10.2147/ott.s106345
• Publication Date: 2016-08-17T00:57:09Z
• Authors: Zhi-Dong Liu; Yi Han; Kang Shi; Shi-Jie Zhou; Da-Ping Yu
• Keywords: 0301 basic medicine; 03 medical and health sciences; OncoTargets and Therapy; Original Research; 3. Good health

The hMLH1 gene plays an essential role in DNA repair. Methylation of the is common many types cancer and can lead to loss expression. However, association clinicopathological significance between promoter hypermethylation non-small-cell lung (NSCLC) elusive. Here, we investigated correlation NSCLC using 13 studies by comprising 1,056 patients via a meta-analysis. We observed that 1) protein expression was significantly associated with its hypermethylation, 2) inactivation through contributed tumorigenesis NSCLC, which could be decisive factor for pathogenesis due high occurrence tissues compared normal tissues, 3) exists histologic subtypes/disease stages (TNM I+II vs III+IV) status gene, 4) subsequent low levels have short overall survival period than those gene. mRNA predicts patient cancer, this confirmed public database. then discussed tumor suppressor function NSCLC. concluded should early diagnostic marker also prognostic index interesting therapeutic target human cancers.