Long-term outcomes of neoadjuvant chemotherapy followed by concurrent chemoradiotherapy (CCRT) vs CCRT alone for nasopharyngeal carcinoma in the era of intensity-modulated radiation therapy using propensity score matching method

• DOI: 10.2147/ott.s135590
• Publication Date: 2017-06-11T23:45:43Z
• Authors: Xueling Chen; Xiaodong Zhu; Zhongguo Liang; Ling Li; Song Qu; Kaihua Chen; Xinbin Pan
• Keywords: Chemoradiotherapy

Purpose: Whether neoadjuvant chemotherapy (NCT) followed by concurrent chemoradiotherapy (CCRT) could improve survival in nasopharyngeal carcinoma (NPC) remains controversial especially the era of intensity-modulated radiation therapy (IMRT), and we explored role NCT for NPC patients. Patients methods: A retrospective review was conducted 255 patients treated with NCT+CCRT (n=67) or CCRT alone (n=188) based on IMRT between December 2006 2012. To control imbalance, a 1:2 match performed using propensity score matching (PSM) method patient’s heterogeneity regimens ­chemotherapy (CCT). The long-term treatment outcomes toxicity group (CRT) (n=134) after PSM were compared. Results: 5-year overall (OS), progression-free (PFS), recurrence-free (RFS), local (LRFS), regional (RRFS) distant failure-free (DFFS) 78.8%, 69.1%, 90.0%, 100% 78.3% group, while 79.5%, 75.7%, 92.7%, 94.2%, 96.1% 82.7% CRT ( P =0.305, 0.448, 0.790, 0.512, 0.104 0.671). It indicated that (NCT+CCRT vs CCRT) not independent prognostic factor patients, only who had completed at least two cycles CCT got better OS, RFS DFFS =0.009, 0.016 0.043), whether to receive not. No difference incidences any acute most late groups shown. Conclusion: Our study did show exact advantage compared higher group. suggests might be necessary if more are finished well IMRT, when is well, less than enough. However, still needs further explored. Keywords: matching, PSM, carcinoma, chemotherapy,