<p>AEG-1 promotes the growth of gastric cancer through the upregulation of eIF4E expression</p>

• DOI: 10.2147/ott.s213604
• Publication Date: 2019-07-22T03:31:32Z
• Authors: Shengjie Wu; Zuhao Zhang; Dandan Wu; Hongling Chen; Xixi Qian; Xuerong Wang; Wenbin Huang
• Keywords: Cyclin B

Background: AEG-1 has been proven to be tumor enhancer in gastric cancer. However, its mechanism not yet fully clarified. Methods: Gain-of-function and loss-of-function experiments were conducted determine the role of eIF4E AEG-1-induced growth cancer cells xenografts a nude mouse model. Western blot analysis SRB assay used protein expression levels survival cell numbers. Results: Silencing inhibited parallel with decreased cyclin D1 expression; however, overexpression promoted increased expression. Moreover, partially reversed silencing-induced reduction inhibition growth. An knockdown also overexpression-induced upregulation Notably, manipulating did affect AEG-1. Finally, silencing SGC-7901 downregulation Conclusion: through eIF4E/cyclin signaling pathway.