<p>Decitabine-containing G-CSF priming regimen overcomes resistance of primary mediastinal neoplasm from early T-cell precursors to conventional chemotherapy: a case report</p>

Decitabine Regimen Priming (agriculture) Chemotherapy regimen Neoplasm
DOI: 10.2147/ott.s214905 Publication Date: 2019-08-28T22:39:37Z
ABSTRACT
Abstract: Early T-cell precursor (ETP) leukemia represents a new subtype of T-lymphoblastic leukemia/lymphoma with unique immunophenotypes expressing and one or more the myeloid/stem cell markers. Here, we report young patient who had primary mediastinal mass pleural effusion without bone marrow involvement. A CT-guided biopsy flow cytometry analysis revealed blast cells to have complicated immunophenotypes: strongly expressed antigen CD7, myeloid-lineage antigens CD33 CD13 stem markers cTdT, CD34, HLA-DR; dimly specific cMPO B-cell cCD79a; but did not express cytoplasmic CD3 CD19. Clonal receptor rearrangement eventually determined origin from ETPs, myeloblasts. The showed resistance lymphoid myeloid-directed induction therapy. Finally, low-dose decitabine combined modified-CAG regimen induced complete remission allogeneic transplantation was performed as consolidation. case indicates neoplasm ETP distinctive immunophenotype type. Low-dose in combination may improve outcome patient. Keywords: early precursor, decitabine, G-CSF priming, lymphoma
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