<p>Decitabine-containing G-CSF priming regimen overcomes resistance of primary mediastinal neoplasm from early T-cell precursors to conventional chemotherapy: a case report</p>

• DOI: 10.2147/ott.s214905
• Publication Date: 2019-08-28T22:39:37Z
• Authors: Yuhuan Yang; Shuna Yao; Jiuyang Zhang; Zheng Yan; Junfeng Chu; Haiying Wang; Zhihua Yao; Fan Zhang; Qingxin Xia; Yanyan Liu
• Keywords: Decitabine; Regimen; Priming (agriculture); Chemotherapy regimen; Neoplasm

Abstract: Early T-cell precursor (ETP) leukemia represents a new subtype of T-lymphoblastic leukemia/lymphoma with unique immunophenotypes expressing and one or more the myeloid/stem cell markers. Here, we report young patient who had primary mediastinal mass pleural effusion without bone marrow involvement. A CT-guided biopsy flow cytometry analysis revealed blast cells to have complicated immunophenotypes: strongly expressed antigen CD7, myeloid-lineage antigens CD33 CD13 stem markers cTdT, CD34, HLA-DR; dimly specific cMPO B-cell cCD79a; but did not express cytoplasmic CD3 CD19. Clonal receptor rearrangement eventually determined origin from ETPs, myeloblasts. The showed resistance lymphoid myeloid-directed induction therapy. Finally, low-dose decitabine combined modified-CAG regimen induced complete remission allogeneic transplantation was performed as consolidation. case indicates neoplasm ETP distinctive immunophenotype type. Low-dose in combination may improve outcome patient. Keywords: early precursor, decitabine, G-CSF priming, lymphoma