Comparative Transcriptome Provides a Systematic Perspective on Epstein–Barr Virus-Associated Gastric Carcinoma Cell Lines

• DOI: 10.2147/ott.s332513
• Publication Date: 2021-10-23T00:00:07Z
• Authors: Jun-Ting Huang; Jian-Ning Chen; Yuan-Hua Bi; Li-Ping Gong; Jing-Yue Zhang; Yu Du; Chun-Kui Shao
• Keywords: Circular RNA

Epstein-Barr virus (EBV) is widely recognised to cause various tumours, and EBV-associated gastric carcinoma (EBVaGC) a special type of GC. It has obviously different clinical features pathological manifestations from EBV-negative carcinoma, but its progression remains elusive. The underlying cancer viral infection detected by genome-wide transcriptome analysis been demonstrated in numerous diseases. We performed comparative RNA sequencing identify gene expression signatures between GC EBVaGC cell lines. differentially expressed (DE) genes were analysed using ontology pathway enrichment. A total 4438 DE mRNAs, 3650 long non-coding RNAs (lncRNAs), 248 circular (circRNAs) cells after EBV infection, most which highly related oncogenesis. Likewise, EBV-coding also well-supplemented EBVaGC. According bioinformatics, mRNAs may contribute the completion EBV-infected host modulate mitosis. Binding actin participating adherens junctions promote contact are potential function lncRNAs. roles circRNAs enriched DNA repair protein modification, typical example this acting as an miRNA sponge. establishment circRNA-miRNA-mRNA network helps determine key elements This study first systematically reveal landscape EBVaGC, will provide essential resource for genomic, genetic, molecular mechanisms future.