Current management options for recurrent adrenocortical carcinoma

• DOI: 10.2147/ott.s34956
• Publication Date: 2013-06-06T00:51:34Z
• Authors: Stanley Sidhu; Glover; Ip; Zhao; Soon; Robinson
• Keywords: Mitotane; Systemic therapy

Abstract: Adrenal cortical carcinoma (ACC) is a rare cancer that poses number of management challenges due to the limited effective systemic treatments. Complete surgical resection offers best chance long-term survival. However, despite complete resection, ACC associated with high recurrence rates. This review will discuss recurrent in adults following resection. Management should take place specialist center and treatment decisions must consider individual tumor biology each case recurrence. Given fact commonly recurs, prevent be considered from initial diagnosis use adjuvant mitotane. Close follow up clinical examination imaging important for early detection disease. Locoregional may isolated, repeat along The radiotherapy remains controversial. Systemic most often involves liver, pulmonary, bone metastasis usually managed mitotane, or without combination chemotherapy. There role selected patients. In all patients disease, control excessive hormone production an part management. Despite intensive ACC, failure common trials novel Keywords: recurrence, surgery, chemotherapy,