High Intelectin‐1 Expression Associated with Aggressive Tumor Behavior and Worse Survival in Rectal Cancer

• DOI: 10.2147/ott.s488608
• Publication Date: 2025-01-13T09:45:11Z
• Authors: Chia-Lin Chou; Cheng-Wei Lin; Wan-Shan Li; Tzu-Ju Chen; Sung-Wei Lee; Yu-Feng Tian; Yu-Hsuan Kuo; Hsin-Hwa Tsai; Li-Ching Wu; Cheng-Fa Yeh; Yow-Ling Shiue; Hong-Yue Lai; Ching-Chieh Yang
• Keywords: Expression (computer science)

Multimodal treatment involving preoperative chemoradiotherapy (CRT) followed by surgery is the current standard of care for rectal cancer. Despite advancements, risk recurrence, metastasis, and decreased survival remains high. This study aims to evaluate potential biomarkers stratify prognosis in patients with cancer undergoing CRT surgery. Through data mining receptor-binding pathways a published transcriptome cases, ITLN1 was identified as most relevant gene associated poor response chemoradiation (GO:0005102). Rectal specimens (n = 343) collected between 1998 2017 were analyzed expression using immunohistochemistry. The association protein clinicopathological features assessed Pearson's chi-square test. Survival outcomes based on evaluated Kaplan-Meier method compared Log rank tests. immunoreactivity significantly elevated tumor tissues. High strongly adverse features, including advanced post-treatment status (T3-4; p 0.001), nodal (N1-2; < vascular invasion (p 0.017), perineural lower degree regression 0.009). Uni- multivariable analyses revealed that high correlated poorer disease-specific survival, local recurrence-free distant metastasis-free low expression. Elevated aggressive behavior unfavorable These findings highlight prognostic biomarker provide foundation future research into its role progression response.