CXCL11: A Novel Biomarker in Colorectal Cancer as Metastasis Predictor

• DOI: 10.2147/ott.s515119
• Publication Date: 2025-05-14T08:40:12Z
• Authors: Riyadi Wibowo; Yunia Sribudiani; Kiki Lukman; Reno Rudiman; Tommy Ruchimat; Bambang Am Am Set...; Andriana Purnama; Alma Wijaya; Etis Primastari; Prapanca Nugraha

CXCL11 (C-X-C motif chemokine ligand 11) encodes a chemokine, small signaling protein involved in immune and inflammatory responses. This study aims to evaluate the association between gene expression variations metastasis colorectal cancer (CRC) patients, highlighting its potential as biomarker for metastasis. is observational laboratory-based utilized tissue samples from patients stored Tissue Bank of Research Unit, Division Digestive Surgery, Faculty Medicine, Universitas Padjadjaran. Conducted January August 2024, data collection pathological anatomical assessments obtained through biopsies or tumor resections. Gene analysis was performed on 60 fresh tissues using PCR at Biomolecular Laboratory, The findings revealed significant variation among CRC based stage (P = 0.015) status 0.017). However, no differences were observed concerning age, gender, pathology, location. identifies relationship patients. Further studies with larger sample sizes are recommended validate CXCL11's role Additionally, future research should explore application antitumor therapy.