Effect of onion flavonoids on colorectal cancer with hyperlipidemia: an in vivo study

• DOI: 10.2147/ott.s51835
• Publication Date: 2014-01-09T00:23:38Z
• Authors: Yongshan He; Heiying Jin; Chunxia Zhang; Wei Gong; Acheng Zhou
• Keywords: Hyperlipidemia

This study aims to find the effect of onion's extraction on colorectal cancer with hyperlipidemia.We established a hyperlipidemia-subcutaneously heterotopic orthotopic transplant model and fed mice high fat diet performing transplantation. Animal models were treated capecitabine and/or simvastatin low-, middle-, high- dose both tumor growth rate blood lipid levels monitored.We found that in groups was significantly inhibited, equivalent capecitabine. Onion's effectively decreased apoB TC.Our hyperlipidemia colon involving subcutaneous translocation transplantation, this an ideal research for mutual influence cancer. could inhibit proliferation cancer; function high-dose fairly capecitabine, which provided new direction protecting treating