MicroRNA-212 inhibits hepatocellular carcinoma cell proliferation and induces apoptosis by targeting FOXA1

• DOI: 10.2147/ott.s87976
• Publication Date: 2015-08-25T02:11:29Z
• Authors: Tiancai Zeng; Huahua Tu; Gang Wei; Qinghe Cai; Xianxiang Chen; Zequn Sun; Caitao Cheng; Linfei Zhang; Yong Feng; Huadong Zhou; Bo Zhou
• Keywords: FOXA1

Abstract: MircroRNA-212 (miR-212) is proposed as a novel tumor-related miRNA and has been found to be significantly deregulated in human cancers. In this study, the miR-212 expression was obviously downregulated hepatocellular carcinoma (HCC) tissues compared with adjacent nontumor tissues. Clinical association analysis indicated that low of prominently correlated poor prognostic features HCC, including high AFP level, large tumor size, Edmondson-Steiner grading, advanced tumor-node-metastasis stage. Furthermore, an independent marker for predicting both 5-year overall survival disease-free HCC patients. Our vitro studies showed upregulation inhibited cell proliferation induced apoptosis HepG2 cells. On contrary, downregulation promoted suppressed Huh7 Interestingly, we decreased FOXA1 Significantly, identified direct target HCC. noncancerous An inverse correlation between observed Notably, knockdown conclusion, potent may suppress growth by inhibiting expression. Keywords: microRNA-212, carcinoma, proliferation, apoptosis,