A high LDL-C to HDL-C ratio predicts poor prognosis for initially metastatic colorectal cancer patients with elevations in LDL-C

• DOI: 10.2147/ott.s90479
• Publication Date: 2015-10-28T02:15:38Z
• Authors: Fangxin Liao; Wen-zhuo He; Chang Jiang; Chen-xi Yin; Gui-fang Guo; Xuxian Chen; Huijuan Qiu; Yu-ming Rong; Bei Zhang; Dazhi Xu; Liang-ping Xia
• Keywords: Univariate analysis; High-density lipoprotein

Although lipid disequilibrium has been documented for several types of cancer including colorectal (CRC), it remains unknown whether parameters are associated with the outcome metastatic CRC (mCRC) patients. Here, we retrospectively examined profiles 453 mCRC patients and investigated any correlated Pretreatment serum lipids, triglyceride, cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C), were collected in initially The LDL-C to HDL-C ratio (LHR) was calculated divided into first, second, third tertiles. Univariate multivariate analyses performed evaluate impact lipids on overall survival (OS) progression-free (PFS). Nearly two-fifths (41.3%) exhibited elevations while most (88.3%) showed normal levels. Decreased (P=0.542) increased (P=0.023) prognostic factors poor OS, triglyceride (P=0.215) not. Multivariate analysis revealed that (P=0.031) an independent factor. Triglyceride, HDL-C, did not correlate PFS. Among levels, tertile LHR had a markedly shorter median OS compared those first or second (P=0.012). Thus, level is factor prognosis patients, high predicts LDL-C.