Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis

• DOI: 10.2147/ott.s94300
• Publication Date: 2015-11-19T23:19:29Z
• Authors: Guo-Chen Duan; Qing-tao Zhao; Tao Guo; Hui-En Wang; Xiao-Peng Zhang; Hua Zhang; Zhi-Kang Wang; Zheng Yuan
• Keywords: Value (mathematics)

The diagnostic value of SHOX2 DNA methylation in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess accuracy the lymph node, bronchial aspirates, pleural effusion, plasma, tumor tissue for cancer. We conducted comprehensive literature search PubMed, Ovid, Cochrane library, Web Science databases May 2015. sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative (NLR), odds (DOR), summary receiver operating characteristic (SROC) curve were pooled using STATA 12.0 software. A total 2,296 subjects included 1,129 eight studies recruited this meta-analysis. estimates diagnosis these SEN =0.70 (95% confidence interval [CI]: 0.46-0.87), SPE =0.96 CI: 0.91-0.99), PLR 20.01 6.96-57.52), NLR 0.31 0.15-0.64), DOR 65.11 13.10-323.61), area under (AUC) was 0.96 0.94-0.97). has greater detecting In addition, considering potential publication bias high heterogeneity, further research more well-designed large sample sizes are needed future.