Heme Metabolism-Related Gene TENT5C is a Prognostic Marker and Investigating Its Immunological Role in Colon Cancer

• DOI: 10.2147/pgpm.s433790
• Publication Date: 2023-12-23T02:35:07Z
• Authors: Wei Han; Cheng Li; Yongheng Wang; Binliang Huo; Wenhan Li; Wen Shi
• Keywords: 0303 health sciences; 03 medical and health sciences; Pharmacogenomics and Personalized Medicine; colon cancer; immune cell infiltrations; heme metabolism; prognosis; Therapeutics. Pharmacology; RM1-950; Original Research

There is a strong correlation between consuming high amounts of heme and an elevated risk developing various types cancer, including colorectal cancer. However, the role metabolism-related genes (HRGs) in cancer remains unclear. Our study aimed to identify prognostic markers for patients based on these genes.The metabolism score was assessed using gene set variation analysis (GSVA). Potential HRGs were identified from TCGA-COAD dataset LASSO COX regression analyses. The expression level TENT5C validated GEO database clinical samples. To explore association immune cell infiltrations, we performed ESTIMATE single-sample enrichment (ssGSEA).The low associated with poor prognosis patients. independent biomarker overall survival. Its confirmed multiple datasets samples, showing positive cells score. GSEA results suggested TENT5C's significant regulating inflammatory responses cancer.TENT5C can be used as Additionally, both infiltration. These findings lay groundwork future research delve into specific development advancement