Persistence with biologic agents for the treatment of rheumatoid arthritis in Japan

• DOI: 10.2147/ppa.s110147
• Publication Date: 2016-08-07T23:10:50Z
• Authors: Jörg Mahlich; Rosarin Sruamsiri
• Keywords: Persistence (discontinuity)

Background: To assess persistence rates of biologic agents for the treatment rheumatoid arthritis in Japan. Methods: Based on Japanese claims data 16,214 patients between 2012 and 2014, 6-, 12-, 18-month different were calculated. Determinants assessed by means a multivariate Cox proportional hazard model controlling age, sex, comorbidities. A sensitivity analysis was performed with definitions parametric survival analysis. Results: Overall Japan are high reach 86% after 1 year entire sample. The rate biologic-naïve subpopulation is above 95%. Persistence higher older (hazard ratio 0.60 [95% confidence interval 0.40–0.91] >75 years compared to ≤60 years) lower comorbidity score 1.33; 95% 1.03–1.70 Charlson Comorbidity Index 3–5 ≤2). We found variation drugs. Conclusion: have treatments. However, multiple factors affect patients, including comorbidities, patient type. Naïve tend than continuing patients. Keywords: Japan, arthritis, database analysis, persistence, biologics