Changes in adherence and associated factors among patients on newly introduced prostaglandin analog and timolol fixed-combination therapy

• DOI: 10.2147/ppa.s168921
• Publication Date: 2018-08-27T00:32:02Z
• Authors: Yuka Hasebe; KENJI KASHIWAGI; Toyoaki Tsumura; Yasuyuki Suzuki; Keiji Yoshikawa; Hirotaka Suzumura; TOSHINE MAEDA; Ryuji Takeda; Hitomi Saito; Makoto Araie
• Keywords: Prostaglandin analogue; Eye drop

We investigated patient adherence and factors related to a newly introduced prostaglandin analog timolol fixed-combination eye drops (PGTFC).The Glaucoma Research on Adherence fixed-Combination Eye in Japan (GRACE) study group performed nationwide prospective questionnaire survey. Participants this were patients with glaucoma who scheduled receive any type of PGTFC for the first time. The participants answered day introduction again at return visit 4-6 weeks after introduction. physicians charge asked complete separate One two leaflets was randomly delivered each participant before description PGTFC. leaflet explained how correctly instill drops, other clinical meaning intraocular pressure reduction addition explaining drops. Nonadherence defined as forgetting one or more times during week visit.In total, 3,597 (age, 68.4±12.2 years) met protocol requirements. significantly reduced number antiglaucoma from 1.93±0.78 1.34±0.54 (P<0.0001) improved (P<0.00001). Factors associated nonadherence included history reported by either their physician introduction, acceptable instillation patient, burdensome drop patient. No significant difference observed between terms effects adherence.PGTFC some that adherence.UMIN000013696.