Correlation Between Long-Term Acetylsalicylic Acid Use and Prostate Cancer Screening with PSA. Should We Reduce the PSA Cut-off for Patients in Chronic Therapy? A Multicenter Study

• DOI: 10.2147/rru.s377510
• Publication Date: 2022-10-21T01:55:06Z
• Authors: Guglielmo Mantica; Francesco Chierigo; Farzana Cassim; Francesca Ambrosini; Stefano Tappero; Rafaela Malinaric; Stefano Parodi; Andrea Benelli; Federico Dotta; Marco Ennas; Martina Beverini; Chiara Vaccaro; Salvatore Smelzo; Giovanni Guano; Federico Mariano; Calogero Paola; Giorgia Granelli; Virginia Varca; Carlo Introini; Salvatore Dioguardi; Alchiede Simonato; Andrea Gregori; Franco Gaboardi; Carlo Terrone; André Van der Merwe
• Keywords: Prostate biopsy; Rectal examination

To evaluate the prostate cancer (PCa) detection rate in men with chronic use of Aspirin and to compare it non-users.Prospectively maintained database regarding patients undergoing biopsy over last 10 years five institutions. Patients were divided into two groups according their exposure Aspirin. We relied on multivariable linear logistic regression models test whether administration was associated lower PSA values at biopsy, higher PCa diagnosis, Gleason Grade Grouping (GGG) biopsy.Were identified 1059 patients, whom 803 (76%) did not take vs 256 (24%) taking it. In log-linear analysis, levels (OR 0.83, 95% CI 0.71-0.97, p = 0.01), after controlling for age, volume, smoking history, inflammation presence GGG. found be a predictor 1.40, 0.82-2.40, 0.21) PSA, findings digital rectal examination number cores. (n 516), predict GGG 2.24, 1.01-4.87, 0.04).Aspirin more aggressive These suggest that threshold should considered Aspirin, as, despite low levels, they might harbour PCa.