Impact of statins on risk of new onset diabetes mellitus: a population-based cohort study using the Korean National Health Insurance claims database

• DOI: 10.2147/tcrm.s117150
• Publication Date: 2016-10-12T02:22:13Z
• Authors: Jimin Lee; Yoojin Noh; Sooyoung Shin; Hong-Seok Lim; Rae Woong Park; Soo Kyung Bae; Euichaul Oh; Grace Juyun Kim; Ju Han Kim; Sukhyang Lee
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Therapeutics and Clinical Risk Management; Original Research; 3. Good health

Statin therapy is beneficial in reducing cardiovascular events and mortalities patients with atherosclerotic diseases. Yet, there have been concerns of increased risk diabetes statin use. This study was aimed to evaluate the association between statins new onset mellitus (NODM) ischemic heart disease (IHD) utilizing Korean Health Insurance Review Assessment Service claims database. Among adult preexisting IHD, users matched nonstatin were identified on a 1:1 ratio using proportionate stratified random sampling by sex age. They subsequently propensity score further age comorbidities reduce selection bias. Overall incidence rates, cumulative rates hazard ratios (HRs) use occurrence NODM estimated. The subgroup analyses performed according sex, groups, individual agents intensities statins. A total 156,360 (94,370 61,990 users) included analysis. 7.8% 4.8% users, respectively. higher among (crude HR 2.01, 95% confidence interval [CI] 1.93-2.10; adjusted 1.84, CI 1.63-2.09). Pravastatin had lowest (adjusted 1.54, 1.32-1.81) while those who exposed more than one at highest 2.17, 1.93-2.37). It has concluded that all are associated it believed our would contribute better understanding analyzing real-world setting. Periodic screening monitoring for warranted during prolonged IHD.