Long-Term Consequences of Increased Activity of Urine Enzymes After Cardiac Surgery – A Prospective Observational Study

• DOI: 10.2147/tcrm.s371288
• Publication Date: 2022-08-25T15:20:08Z
• Authors: Jowita Biernawska; Katarzyna Kotfis; Jolanta Szymańska...; Anna Bogacka; Joanna Bober
• Keywords: b-gr; Therapeutics and Clinical Risk Management; asa; beta-glucuronidase; RM1-950; nag; arylsulfatase a; 6. Clean water; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; acute kidney injury; aki; n-acetyl-beta-glucosaminidase; Therapeutics. Pharmacology; cardiac surgery; Original Research

Introduction: Cardiac surgery associated AKI (CSA-AKI) complicates recovery and may be with a greater risk of developing chronic kidney disease mortality. The aim this study was to assess long-term clinical consequences transient increased activity urinary enzymes after cardiac (CS). Methods: An observational conducted in group 88 adult patients undergoing planned coronary artery bypass grafting (CABG), but all samples were obtained from 79 patients. enzymes: N-acetyl-beta-glucosaminidase (NAG), arylsulfatase A (ASA) beta-glucuronidase evaluated sequential urine samples. comparative analysis biochemical parameters performed regarding the occurrence acute injury (AKI) defined by KIDGO at 24 hours, day 30 5-years operation. Results: During first hours CS diagnosed 13 comparison pre-defined time-points showed significant differences for ASA NAG (post OP-sample p < 0.028 0.022; POD 1 sample 0.004 0.001 respectively). No patient had any or features failure 30. In 36% within 5 years follow-up as opposed 5% no group. activities tubular reflect general tubules during However, they are not ideal biomarkers prediction degree further poor prognosis CS-AKI. Keywords: injury, AKI, N-acetyl-beta-glucosaminidase, NAG, A, ASA, beta-glucuronidase, B-GR,