Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial

• DOI: 10.2147/tcrm.s480272
• Publication Date: 2025-01-23T11:35:12Z
• Authors: Lulan Li; Liupan Zhang; Xixuan Wu; Zhenhua Zeng
• Keywords: Reconstructive Surgery

Patients after head and neck tumor reconstruction surgery frequently require deep sedation analgesia in the ICU. However, risk factors for delirium associated with propofol-based remain unclear. The study aimed to explore of propofol singled or combined sedation. This retrospective analyzed ICU patients who underwent surgery. were divided into three groups: (P), + midazolam (PM), dexmedetomidine (PD) groups. We utilized univariate multivariate logistic regression identify delirium. Delirium occurred 4 (7.02%), 11 (28.21%), 5 (20.83%) P, PM PD groups, respectively. Elevated mean arterial pressure (MAP), increased aspartate aminotransferase (AST) levels, use determined be significant this patient cohort. is strongest predictor delirium, which can increase by 3.218 times (95% CI = 1.041-9.950, p 0.042). Propofol may