Managing infertility with the follitropin alfa prefilled pen injector – patient considerations

• DOI: 10.2147/tcrm.s64222
• Publication Date: 2015-06-29T23:12:05Z
• Authors: Klaus Bühler
• Keywords: Gonadotropin; Menotropins

Gonadotropin treatment has been used in fertility since the 1930s. First, preparations coming from animals were injected, then, gonadotropins prepared pituitary glands of human cadavers. A great step was achieved with introduction menopausal gonadotropin extracted urine postmenopausal women. When cases Creutzfeld-Jacob disease recognized after use pituitary-derived hormone injections, urinary increasingly purified and then produced by recombinant DNA technology. Recombinant characterized extreme high specificity nearly 100% purity. This allows for follitropin alfa, first recombinant-human follicle stimulating (r-hFSH) approved, to be quantified filled mass, a small variance only ±2% no more bioassay 45%. With preparations, it is also possible cover tremendous growing demand gonadotropins. Ovarian stimulation become self-injecting procedure patients. Accurate easy-to-use injection devices which minimize pain, difficulty, stress are essential patient compliance. So, two pen injectors adapted well-known insulin introduced treatment, one as multiple-use device rechargeable premixed, prefilled cartridges r-hFSH (follitropin β) other disposable, drug delivery system liquid formulation alfa mass. The efficacy comparison quite cumbersome handling ampoules syringes proven very quickly. In several studies, shown that patients had preference due faster preparation confident accurate dosing. (filled mass [FbM]) move toward better quality life women within stressful period treatment.