Polymorphisms of <i>HSD17B13</i>, <i>GCKR</i>, <i>HFE</i>, and <i>CP</i> as factors of the development of non-alcoholic fatty liver disease and comorbid diseases

• DOI: 10.21518/ms2022-026
• Publication Date: 2023-05-29T09:09:26Z
• Authors: O. V. Smirnova; D. V. Lagutinskaya
• Keywords: Steatosis; Steatohepatitis

Currently, non-alcoholic fatty liver disease is one of the most common chronic diseases. In recent years, this condition has been considered as a hepatic manifestation metabolic syndrome, which associated with overweight and impaired glucose fat metabolism. Despite obvious role lifestyle in development disease, it increasingly being suggested that disorders metabolism fats carbohydrates have genetic basis, determines tendency to develop NAFLD. Mutant polymorphisms HSD17B13 , GCKR HFE CP genes shown affect course NAFLD, but these effects require further study. Therefore, aim work was analyze systematize available data from foreign articles over past 10 years. study, 573 were analyzed, important 64 original research works used here. Mutations gene are milder while polymorphisms, on contrary, more severe histological manifestations such steatosis fibrosis. The genes, although not directly related macronutrient metabolism, nevertheless contribute forms may be inflammation oxidative stress caused by excessive accumulation iron hepatocytes.