Changes of tumor and normal structures of the neck during radiation therapy for head and neck cancer requires adaptive strategy

• DOI: 10.2152/jmi.60.46
• Publication Date: 2015-06-18T18:06:21Z
• Authors: Ryota Bando; Hitoshi Ikushima; Takashi Kawanaka; Takaharu Kudo; Motoharu Sasaki; Masahide Tominaga; Taro Kishi; Shunsuke Furutani; Akiko Kubo; Koichi Tamura
• Keywords: Mucositis

The treatment period over which radiation therapy is administered extends several weeks. Since tumor shrinkage in response to and weight loss due radiation-induced mucositis may impact on the dose distribution both target organ at risk patients with head neck cancer, anatomical changes of volumes during this should be taken into consideration. We investigated that occurred normal structure for pharyngeal evaluated necessity an adaptive strategy. Ten cancer who underwent radical chemoradiation using 3-dimensional conformal RT (66-70 Gy 33-35 fractions) between April 2009 September 2010 were enrolled study. Patients CT scans every week their course treatment. analyzed data planning system measured tumor, risk, volume. Gross volume (GTV) was rapidly reduced by 28% original average first 3 right left submandibular glands decreased 70% 63% initial average, respectively. fields 89% its sixth mainly caused body acute morbidity. Considerable change filed will affect observed cancer. J. Med. Invest. 60: 46-51, February, 2013