Anti-Parasite and Cytotoxic Activities of Chloro and Bromo L-Tyrosine Derivatives

• DOI: 10.21577/0103-5053.20180136
• Publication Date: 2018-07-16T09:26:00Z
• Authors: Manuel Restrepo; Elkin Jaramillo; Alejandro Martínez; Ana Arango; Sara Restrepo
• Keywords: 0301 basic medicine; Cytotoxicity; Plasmodium falciparum; 610; Citotoxicidad; P. falciparum; 540; 3. Good health; http://aims.fao.org/aos/agrovoc/c_34251; cytotoxic; 03 medical and health sciences; L. panamensis; Tirosina; Tyrosine; Leishmania guyanensis; L-tyrosine

A series of twenty-one L-tyrosine derivatives with modifications in the halogenation pattern aromatic ring and different degree methylations on amine phenolic hydroxyl groups were synthesized.The structures all intermediates target compounds confirmed unambiguous by spectroscopy analysis.Additionally, evaluated against Plasmodium falciparum Leishmania panamensis parasites between 20-702 µg mL -1 .The cytotoxic evaluation was done to determine selectivity index for each compound.Six had lower EC 50 (effective concentration 50) L. panamensis.One these most active an at 24.13 (76.07 µM).All showed no significant activity P. compound has vitro antifungal 500 .