An Investigation into Hematoprotective and Antioxidant Effects of Salvia virgata Jacq. Upon Cyclophosphamide-Induced Toxicity

• DOI: 10.21597/jist.1007441
• Publication Date: 2022-05-25T11:07:44Z
• Authors: İlknur KULCANAY Ş...
• Keywords: Malondialdehyde; Salvia

The present study aims to investigate hematoprotective and antioxidant effects of Salvia virgata (SV) on Cyclophosphamide (CP)-induced toxicity. rats were divided into 6 groups 7 members each. These the Control group, CP Group (150 mg kg-1), 100 200 kg-1 SV Groups, CP+100 CP+200 Groups. All sacrificed harvest their blood bone marrow samples day after final injections. While some used for leukocyte platelet count, others determine levels total capacity (TAC), malondialdehyde (MDA), oxidant status (TOS), glutathione (GSH), oxidative stress index (OSI). a decrease was observed in leukocyte, bone-marrow nucleated cell counts group given CP, apart from decline GSH TAC levels, MDA TOC this showed an increase. In contrast, CP-induced myelosuppression reversed combined Groups (CP+100 Groups), although reversal latter more significance. Our experimental results have shown that may exert cytoprotective upon CP-related peripheral toxicities.