Cytotoxicity and antimicrobial activities of some soft corals inhabiting the red sea, Egypt.

• DOI: 10.21608/absb.2021.87211.1128
• Publication Date: 2021-10-23T15:34:51Z
• Authors: Abdallah Alian; Abo bakr Abdel Sh...; Khaled -Geba; Alaa Osman
• Keywords: Broth microdilution; MTT assay; IC50

Cancer and infectious diseases are notoriously known as deleterious health threats for the world, especially in developing countries.The aim of present study was to evaluate cytotoxicity antimicrobial activities methanolic extracts soft corals Nephthea elatensis, Heteroxenia fuscescens, Ellisella juncea, Dendronephthya mollis, Sinularia hirta, that native Red Sea Egypt.The assay carried out by enzymatic reduction 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) against lung adenocarcinoma cell line (A549).Moreover, activity 11 human pathogenic bacterial fungal strains using well-cut diffusion technique, while Minimum Inhibitory Concentrations (MICs) were determined microdilution method.Nephthea elatensis showed potent [half maximal inhibitory concentration (IC50) 11.9 ± 1.2 µg/mL].Also, it exhibited a antibacterial Staphylococcus aureus (MIC 1.0 µg/mL).Sinularia hirta significant Salmonella typhimurium S. 5.0 10.0 µg/mL, respectively).The results recommended N. promising sources new anticancer antibiotic natural candidates.