A Comprehensive Overview of Lipid-Based Drug Delivery Approach

• DOI: 10.21608/rpbs.2022.231970
• Publication Date: 2022-04-25T06:52:13Z
• Authors: Noha Abourobe; Tamer Hassan; shadeed Gad; Yasser Mostafa

The majority of the pharmaceutically active chemical moieties represent a challenge in their formulation. Most these drugs have intricate bioavailability issues either related to low solubility or permeability. Many problems may arise during formulations such as pH dependent ionization, poor drug solubility, limited absorption, unpredicted bioavailability, degradation, metabolism, and cellular efflux. Poor aqueous is determinate criterion, formulation Biopharmaceutical Classification System (BCS) categorization. Among most important approaches enhance Lipid-Based Drug Delivery Systems (LBDDS). strategies involving lipid incorporation was revolutionary step included: vesicular systems, particulate systems emulsions.