Comparative Effect of Stevia and Aspartame Sweeteners: A Biochemical, Sero-Biochemical, Histochemical and Immunohistochemical Study

• DOI: 10.21608/scvmj.2023.307764
• Publication Date: 2023-07-17T18:09:29Z
• Authors: Eman Sameh; kawther Elhady; Sahar Srour; Reham El-Tarabili; Ahmed Eltahan; Rania Abdou
• Keywords: Aspartame; Stevia; Artificial Sweetener; Saccharin

Aspartame is a common artificial sweetener that thought to be dangerous.On the other hand, stevioside (stevia) natural of plant origin was assumed alternative sweeteners.This study aimed determine whether aspartame or affected biochemical, sero-biochemical, and immunohistochemical changes in adult rats following six weeks exposure.Forty-eight were used divided into three groups: Group I: control group, II: received (75 mg/kg/day), III: (45 mg/kg/day).All medications given orally for 6 weeks.Lipid Peroxidation product (MDA); liver glutathione (GSH); nitric oxide (NO); Liver Superoxidase dismutase activity(SOD); catalase (CAT), Low-density lipoprotein (LDL) ; very low (VLDL) ;the cholesterol HDL; Alanine Aminotransferase (ALT), Aspartate (AST); Creatinine, Urea, Total proteins assessed blood tissue specimens.In addition, hepatic histopathological investigations done.Aspartame group showed significant increase most investigated biochemical parameters (especially glucose, MDA, NO, LDL, VLDL, ALT, AST, creatinine urea) with decrease serum albumin endogenous antioxidants (GSH, SOD, CAT) compared while stevia-exposed animals same antioxidants.Moreover, severe changed observed Aspartam-116 Eman Sameh et al. treated animals.However, Stevia-treated least changes.Therefore, it can concluded Stevia less harmful than aspartame.