Nephrotoxicity of Single or Combined Exposure to Microplastics (MPs) and Sodium Lauryl Sulfate (SLS) in African Catfish (Clarias gariepinus)

• DOI: 10.21608/sjsci.2024.270896.1180
• Publication Date: 2024-05-25T07:33:41Z
• Authors: Alyaa El-Sayed; Hamdy Soliman; Fatma Ahmed; Alaa El-Din Sayed
• Keywords: Clarias gariepinus; Nephrotoxicity

It is unclear how fish in freshwater ecosystems are affected by the combined presence of microplastics (MPs) and anionic surfactant detergents. So, our investigations focus on nephrotoxic effects both Polyethylene (PE-MPs) Sodium lauryl sulfate (SLS) single or exposure African Catfish (Clarias gariepinus). In current study, rearing water catfish gariepinus) was supplied with 0, 10 mg/L PE-MPs, 4 SLS, their combination for 15 days. Blood analysis kidney functions histological appraisals renal tissue integrity, collagen density (types I & III), polysaccharide deposits were investigated. Exposure to irregular-shaped PE-MPs (10 mg/L) SLS (4 revealed nephrotoxicity affecting exposed fish. Significant increases serum creatinine uric acid levels severe pathological lesions recorded mg/L)-exposed groups. addition, significantly higher fibrosis as well hypoglycemia observed all groups compared control group. Nevertheless, these substances non-significant differences level mild lower hypoglycemia. conclusion, either singularly combination. Unexpectedly, an antagonistic effect form upon + might be due some interaction between that altered toxicity.