Nanoparticles of Biodegradable Polymers for Clinical Administration of Paclitaxel

• DOI: 10.2174/0929867043455909
• Publication Date: 2005-03-23T00:08:20Z
• Authors: Si-Shen Feng; Li Mu; Khin Win; Guofeng Huang
• Keywords: PLGA

Paclitaxel is one of the best antineoplastic drugs found from nature in past decades, which has been effective against a wide spectrum cancers including ovarian cancer, breast small and non cell lung colon head neck multiple myeloma, melanoma, Kaposis sarcoma. Like many other anticancer drugs, it difficulties clinical administration due to its poor solubility water most pharmaceutical reagents. In current application, an adjuvant called Cremophor EL be employed, responsible for serious side effects. Nanoparticles biodegradable polymers can provide ideal solution such problem realize controlled targeted delivery drug with better efficacy less With further development, as particle size optimization surface coating, nanoparticle formulation paclitaxel promote new concept chemotherapy full improve quality life patients, includes personalized chemotherapy, local sustained oral across blood-brain barrier, microcirculation etc. The present research proposes novel fabrication nanoparticles poly(lactic-co-glycolic acid) (PLGA) by modified solvent extraction / evaporation technique, natural emulsifiers, phospholipids, cholesterol vitamin E TPGS are creatively applied achieve high encapsulation efficiency, desired released kinetics, uptake cytotoxicity. composed various recipes manufactured under conditions were characterized laser light scattering (LLS) distribution, scanning electron microscopy (SEM) atomic force (AFM) morphological properties, X-ray photoelectron spectroscopy (XPS) Fourier Transformation Infrared Spectroscopy (FTIR) chemistry, zeta-potential charge, differential calorimetry (DSC) thermogram properties. efficiency release kinetics vitro measured performance liquid chromatography (HPLC). It was that these emulsifiers have great advantages over traditional macromolecular polyvinyl alcohol (PVA). narrow distribution obtained. achieved 100 %. made control. HT-29 cancer line experiment showed after 24 hours incubation, mortality caused administered could more than 13 times higher free similar conditions. Keywords: Nanoparticles, cholesterol, paclitaxel,