Selective Modifications of Steroids Performed by Oxidative Enzymes

• DOI: 10.2174/138527212804004625
• Publication Date: 2012-11-21T08:34:52Z
• Authors: Alina Swizdor; Teresa Kolek; Anna Panek; Natalia Milecka
• Keywords: Hydroxylation; Biotransformation; Biocatalysis; Oxidative cleavage; Cleavage (geology)

Research on steroid biooxidation is being pursued for development of processes exploitable by the pharmaceutical industry, and also purpose preparation potentially useful analogues which are otherwise inaccessible. The use enzymes provides high regio- stereoselectivity reaction to be performed. In this work a review recent important findings related microbial enzymatic biotransformations steroidal compounds including hydroxylation, Baeyer-Villiger oxidation, dehydrogenation sterol side-chain cleavage presented, with emphasis practical biotechnological importance. Although some these bioconversions well-established, efforts ongoing in order increase their efficiency as well discover novel acquire recombinant microorganisms capable performing desired biotransformations. Keywords: Oxidation, Biotransformation Steroids, Dehydrogenation, Microbial Transformation, Stereoselective Hydroxylation, Sterol Side-Chain Cleavage