Neuroinflammation and Complexes of 17β -Hydroxysteroid Dehydrogenase type 10 - Amyloid β in Alzheimer's Disease

• DOI: 10.2174/1567205011310020006
• Publication Date: 2013-03-14T13:09:47Z
• Authors: Zdena Kristofikova; Daniela Ripova; Ales Bartos; Marketa Bockova; Katerina Hegnerova; Jan Ricny; Linda Cechova; Monika Vrajova; Jiri Homola
• Keywords: Amyloid (mycology)

Multifunctional mitochondrial enzyme 17β-hydroxysteroid dehydrogenase type 10 plays a role in the development of Alzheimer's disease. However, changes its expression brain or cerebrospinal fluid are not fully specific for this dementia. Our previous study revealed that complexes and amyloid β could serve as more biomarker disease than either individually when compared to autoimmune multiple sclerosis. In study, enzyme-linked immunosorbent assay surface plasmon resonance biosensor method were used analyse patients with various neuroinflammatory diseases. Significant differences levels total enzyme, complexes, 1-42 τ/phospho-τ found while 1- 42 observed diseases (except sclerosis) nonneuroinflammatory controls. The interactions appeared depend strongly on neuroinflammation-sensitive β. data demonstrated oligomerisation/aggregation intracellular peptides was important extracellular play Phospho-τ is currently best Keywords: Amyloid β, disease, neuroinflammation